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Journal of Dental Research
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Biglycan is a Repressor of Amelogenin Expression and Enamel Formation: An Emerging Hypothesis

M. Goldberg1,*, D. Septier1, O. Rapoport1, M. Young2 and L. Ameye2,3

1 Laboratoire de Biologie et Physiopathologie Crânio-faciales, Groupe Matrices Extracellulaires et Minéralisations, Faculté de Chirurgie Dentaire, Université Paris V , 1, rue Maurice Arnoux, 92120 Montrouge, France;
2 CSDB, NIDCR, NIH, Bethesda, MD, USA; and
3 Nestlé Research Center, Dept. Nutrition, G35, Vers-chez-les-Blanc, PO Box 44, 1000 Lausanne 26, Switzerland;


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  		Figure. Sections of dental tissues of a day-1 wild-type mouse were immunostained for decorin (DCN) (A) and biglycan (BGN) (B). Both SLRPs were immunodetected in predentin (arrowheads). In addition, positive staining was seen with the anti-BGN alone at the junction between the secretory ameloblasts (a) and the stratum intermedium (arrow). In addition, granules (secretory or re-internalized material) were positively stained for BGN in the distal part of ameloblasts. Odontoblasts (o) were slightly above background labeling.

 

Journal of Dental Research, Vol. 81, No. 8, 520-524 (2002)
DOI: 10.1177/154405910208100804
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