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Dental Fluorosis: Variability among Different Inbred Mouse Strains

¹ Oral-Facial Genetics Division,
² Department of Oral Facial Development,
³ Graduate Program in Pediatric Dentistry,
⁴ Department of Preventive and Community Dentistry, and
⁵ Oral Health Research Institute, Indiana University School of Dentistry, 1121 W. Michigan St., Room 270, Indianapolis, IN 46202;

View larger version (92K): [in this window] [in a new window]   Figure 1. Robust dental fluorosis seen in the A/J strain. Shown are representative A/J and 129P3/J mice after 60 days of treatment (0 ppm, 25 ppm, or 50 ppm fluoride as NaF in the drinking water). Upper and lower incisors of the A/J mice show dramatic color and character changes in response to fluoride. The diffuse yellow-orange color present in the teeth at 0 ppm is typical of normal tooth color development in A/J and other mice. In the 0 ppm treatment group, the lower incisors are translucent as judged by the passing of a periodontal probe behind the teeth. That translucency is not detectable at 25 ppm and 50 ppm [F]. Also in the A/J mice, the labial surfaces of the lower incisors became rough and pitted. At sites where there is a transition (distal aspects), ledges can be detected with probing. The 129P3/J strain is resistant to the development of dental fluorosis. Clinical changes in tooth color and opacity are seen only at the 50-ppm treatment level and are greatly reduced compared with those in A/J mice.

View larger version (30K): [in this window] [in a new window]   Figure 2. Upper incisor color charting. The Vita shade guide color code converted to color groups 1 (whiter), 2 (yellow/tan), or 3 (deep yellow/orange), and the average value for the 6 mice from each strain per treatment group plotted over time in wks (Panels: A = 129P3/J; B = A/J; C = BALB/cJ; D = C3H/HeJ; E = C57BL/6J; F = C57BL/10J; G = CBA/J; H = FVB/NJ; I = SJL/J; and J = SWR/J). These data show that mouse strains respond differently to fluoride treatment and that tooth color changes are dose-responsive. 0 ppm [F] = solid circles with dashed lines, 25 ppm = solid squares, and 50 ppm = solid triangles.

Journal of Dental Research, Vol. 81, No. 11, 794-798 (2002)
DOI: 10.1177/154405910208101114


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