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Journal of Dental Research
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CLINICAL

Neutrophil Response to Dental Plaque by Gender and Race

V.Y. Wahaidi1, S.A. Dowsett1,2, G.J. Eckert3 and M.J. Kowolik1,*

1 Department of Periodontics and Allied Dental Programs, Indiana University School of Dentistry, 1121 West Michigan Street, Indianapolis, IN 46202, USA;
2 Eli Lilly and Company, Indianapolis, IN 46285, USA; and
3 Division of Biostatistics, Indiana University School of Medicine, Indianapolis, IN 46202, USA

Correspondence: * mko-wolik{at}iupui.edu

The inflammatory response, which has both genetic and environmental components, is a central mechanism linking oral and systemic diseases. We hypothesized that dental plaque accumulation over 21 days in the experimental gingivitis model would elicit systemic inflammatory responses [change in white blood cell (WBC) count and neutrophil activity], and that these responses would differ by gender/race. We recruited 156 healthy young adults, including black and white males and females. Plaque Index (PI), Gingival Index (GI), systemic WBC counts, and peripheral neutrophil oxidative activity were recorded. Overall, 128 participants completed the study. During the experimental phase, the correlation between PI and GI was 0.79. Total WBC and neutrophil counts did not change. Neutrophil activity increased in blacks but not whites, suggesting that there may be racial differences in the inflammatory response to dental plaque accumulation.

Key Words: dental plaque • experimental gingivitis • neutrophil

Journal of Dental Research, Vol. 88, No. 8, 709-714 (2009)
DOI: 10.1177/0022034509339019
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