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Journal of Dental Research
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Clinical

Efficacy of Silver Diamine Fluoride for Arresting Caries Treatment

R. Yee1,4,*, C. Holmgren1, J. Mulder1, D. Lama2, D. Walker3 and W. van Palenstein Helderman1

1 Department of Global Oral Health, Radboud University Nijmegen Medical Centre, College of Dental Sciences, PO Box 9101, 6500 HB Nijmegen, The Netherlands;
2 The United Mission to Nepal Oral Health Programme, PO Box 126, Kathmandu, Nepal;
3 Population Oral Health, Faculty of Dentistry, University of Sydney, 1 Mons Road, Westmead, NSW 2145, Australia; and
4 National University Health System (NUHS), Faculty of Dentistry, Department of Preventive Dentistry, Level 2, Dentistry Block, 5 Lower Kent Ridge Road, Singapore 119074

Correspondence: * pndry{at}nus.edu.sg.

Arresting Caries Treatment (ACT) has been proposed to manage untreated dental caries in children. This prospective randomized clinical trial investigated the caries-arresting effectiveness of a single spot application of: (1) 38% silver diamine fluoride (SDF) with tannic acid as a reducing agent; (2) 38% SDF alone; (3) 12% SDF alone; and (4) no SDF application in primary teeth of 976 Nepalese schoolchildren. The a priori null hypothesis was that the different treatments have no effect in arresting active cavitated caries. Only the single application of 38% SDF with or without tannic acid was effective in arresting caries after 6 months (4.5 and 4.2 mean number of arrested surfaces; p < 0.001), after 1 year (4.1 and 3.4; p < 0.001), and after 2 years (2.2 and 2.1; p < 0.01). Tannic acid conferred no additional benefit. ACT with 38% SDF provides an alternative when restorative treatment for primary teeth is not an option.

Key Words: fluorides • silver diamine fluoride • clinical trial • arresting caries treatment

Journal of Dental Research, Vol. 88, No. 7, 644-647 (2009)
DOI: 10.1177/0022034509338671
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