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Journal of Dental Research
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Biological

Cranberry Proanthocyanidins Inhibit MMP Production and Activity

V.D. La1, A.B. Howell2 and D. Grenier1,*

1 Groupe de Recherche en Écologie Buccale, Faculté de Médecine Dentaire, Université Laval, 2420 Rue de la Terrasse, Quebec City, QC, Canada G1V 0A6; and
2 Marucci Center for Blueberry and Cranberry Research, Rutgers, The State University of New Jersey, Chatsworth, NJ 08019, USA

Correspondence: * Daniel.Grenier{at}greb.ulaval.ca

Matrix metalloproteinases (MMPs) produced by resident and inflammatory cells in response to periodontopathogens play a major role in periodontal tissue destruction. Our aim was to investigate the effects of A-type cranberry proanthocyanidins (AC-PACs) on: (i) the production of various MMPs by human monocyte-derived macrophages stimulated with Aggregatibacter actinomycetemcomitans lipopolysaccharide (LPS), and (ii) the catalytic activity of recombinant MMP-1 and MMP-9. The effects of AC-PACs on the expression of 5 protein kinases and the activity of nuclear factor-kappa B (NF-{kappa}B) p65 in macrophages stimulated with LPS were also monitored. Our results indicated that AC-PACs inhibited the production of MMPs in a concentration-dependent manner. Furthermore, the catalytic activity of MMP-1 and MMP-9 was also inhibited. The inhibition of MMP production was associated with reduced phosphorylation of key intracellular kinases and the inhibition of NF-{kappa}B p65 activity. AC-PACs thus show potential for the development of novel host-modulating strategies to inhibit MMP-mediated tissue destruction during periodontitis.

Key Words: cranberry • proanthocyanidins • matrix metalloproteinases • kinase • periodontitis

Journal of Dental Research, Vol. 88, No. 7, 627-632 (2009)
DOI: 10.1177/0022034509339487
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