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Journal of Dental Research
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Biological

A Role for {alpha}11β1 Integrin in the Human Periodontal Ligament

M.M. Barczyk1,2, L.-H. Borge Olsen1, P. da Franca1, B.G. Loos3, K. Mustafa4, D. Gullberg2 and A.I. Bolstad1,*

1 Department of Clinical Dentistry - Periodontics, University of Bergen, Aarstadveien 17, N-5009 Bergen, Norway;
2 Department of Biomedicine - Physiology, University of Bergen, Norway;
3 Department of Periodontology, Academic Center for Dentistry Amsterdam (ACTA), University of Amsterdam and Vrije University, The Netherlands; and
4 Department of Clinical Dentistry—Center for Clinical Dental Research, University of Bergen, Norway

Correspondence: * anne.bolstad{at}iko.uib.no

We previously demonstrated a role for {alpha}11β1 integrin in periodontal ligament (PDL)-driven tooth eruption in the mouse. To explore a possible role for {alpha}11β1 in the human periodontium, we have characterized the expression and function of {alpha}11 in human PDL tissue, in human PDL fibroblasts (hPDLF), and in human gingival fibroblasts (hGF). {alpha}11 expression was detected in PDL tissue, in hPDLF, and in hGF cells. Platelet-derived growth factor-BB and insulin-like growth factor II stimulated contraction of collagen lattices by both types of fibroblasts. {alpha}2 integrin blocking antibodies and the use of {alpha}11 siRNA demonstrated a role for both {alpha}2β1 and {alpha}11β1 in collagen lattice remodeling. Analysis of the proximal ITGA11 promoter from persons with chronic periodontal disease failed to reveal any polymorphism. Analysis of our data shows that {alpha}11β1 is a major collagen receptor on cultured human PDL cells and implies that it is also functionally important in the PDL in vivo.

Key Words: periodontal • ligament • disease • polymorphisms • integrins

Journal of Dental Research, Vol. 88, No. 7, 621-626 (2009)
DOI: 10.1177/0022034509339291
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