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Journal of Dental Research
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Biological

Dental Pulp and Periodontal Ligament Cells Support Osteoclastic Differentiation

M. Uchiyama1,4, Y. Nakamichi2, M. Nakamura3, S. Kinugawa1, H. Yamada4, N. Udagawa1,3,* and H. Miyazawa1,5

1 Graduate School of Oral Medicine,
2 Division of Hard Tissue Research, Institute for Oral Science,
3 Department of Biochemistry,
4 Department of Endodontics and Operative Dentistry, and
5 Department of Pediatric Dentistry, Matsumoto Dental University, 1780 Gobara, Hiro-oka, Shiojiri, Nagano 399-0781, Japan

Correspondence: * udagawa{at}po.mdu.ac.jp

Odontoclasts and cementoclasts are considered to play major roles in the internal resorption of dentin and the external resorption of tooth roots. In this study, we evaluated the osteoclast-inducing ability of human dental pulp and periodontal ligament cells, which are mesenchymal cells in dental tissues. These cells expressed RANKL and OPG mRNA constitutively. As osteoclast precursors, CD14+ monocytes derived from human peripheral blood were isolated, and incubated together with human dental pulp or periodontal ligament cells. Both cell types spontaneously induced the differentiation of CD14+ monocytes into osteoclasts without osteotropic factors. These results suggest that dental pulp and periodontal ligament cells are involved in regulating the differentiation and function of osteoclasts.

Key Words: osteoclasts • dental pulp • periodontal ligament • monocytes • RANKL

Journal of Dental Research, Vol. 88, No. 7, 609-614 (2009)
DOI: 10.1177/0022034509340008
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