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Journal of Dental Research
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Clinical

Amphiregulin Induces Proliferative Activities in Osseous Dysplasia

H. Shigeishi1,*, S. Yamaguchi2, K. Mizuta1, K. Nakakuki2, S. Fujimoto1, T. Amagasa2 and N. Kamata1

1 Department of Oral and Maxillofacial Surgery, Division of Cervico-Gnathostomatology, Graduate School of Biomedical Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8553, Japan; and
2 Maxillofacial Surgery, Graduate School, Tokyo Medical and Dental University, 5-45 Yushima 1-chome, Bunkyo-ku, Tokyo 113-8549, Japan

Correspondence: * shige{at}hiroshima-u.ac.jp

Human osseous dysplasia (OD) is a benign fibro-osseous neoplasm of periodontal ligament origin in which normal bone is replaced with fibrous connective tissue containing abnormal bone or cementum. However, cellular differentiation and proliferation in OD have not been fully elucidated. In vitro culture systems have distinct advantages for analytical studies. Therefore, we established immortalized cell lines (OD-1) from OD lesions of the jaw from an individual with gnathodiaphyseal dysplasia (GDD). We hypothesized that OD-1 had a characteristic growth mechanism different from that of mineralized-associated cells such as osteoblasts. To clarify the difference of gene expression patterns between OD-1 and osteoblasts, we compared the profiles of genes expressed in the 2 cell types by microarray analysis. We identified amphiregulin to be highly expressed in OD-1 compared with osteoblasts and gingival fibroblasts. OD-1 showed proliferative activities regulated in an autocrine manner by amphiregulin, and amphiregulin may play a significant role in the proliferation of OD.

Key Words: osseous dysplasia • gnathodiaphyseal dysplasia • amphiregulin

Journal of Dental Research, Vol. 88, No. 6, 563-568 (2009)
DOI: 10.1177/0022034509338253
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