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Journal of Dental Research
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Biological

Isoproterenol Improves Secretion of Transplanted Submandibular Glands

Y.M. Li1,4,*, Y. Zhang1,*, L. Shi2, B. Xiang2, X. Cong1, Y.Y. Zhang3, L.L. Wu1,{dagger} and G.Y. Yu2,{dagger}

1 Department of Physiology and Pathophysiology, Peking University Health Science Centre and Key Laboratory of Molecular Cardiovascular Sciences, Ministry of Education, Beijing 100191, China;
2 Department of Oral and Maxillofacial Surgery, Peking University School and Hospital of Stomatology, 22 Zhong Guan Cun South St., Beijing 100081, China;
3 Institute of Vascular Medicine, Peking University Third Hospital, Beijing, China; and
4 Department of Physiology and Pathophysiology, Capital Medical University Yanjing Medical College, Beijing, China

Correspondence: {dagger} pathophy{at}bjmu.edu.cn and gyyu{at}263.net

Autotransplantation of the submandibular gland is effective for severe keratoconjunctivitis sicca. However, most transplants show decreased secretion shortly after the operation, which leads to obstruction of Wharton’s duct. The hypothesis that decreased catecholamine release due to denervation contributes to hypofunction in the early phase was tested in transplanted glands in rabbits. We found that salivary flow, expression of β1- and β2-adrenoceptor, and the maximum binding capacity were markedly decreased in the transplanted glands. Isoproterenol significantly reversed the decreased secretion, enhanced the expressions of β1- and β2-adrenoceptor, and ameliorated the atrophy of acinar cells. The contents of cAMP and phospho-ERK 1/2 were increased after isoproterenol treatment. These results indicate that lack of β-adrenoceptor stimulation is involved in early dysfunction of the transplanted gland. Isoproterenol treatment moderates structural injury and improves secretory function in the transplanted submandibular gland through up-regulating β1- and β2-adrenoceptor expression and post-receptor signal transduction.

Key Words: β-adrenoceptor • isoproterenol • rabbit • submandibular gland • transplantation

Journal of Dental Research, Vol. 88, No. 5, 477-482 (2009)
DOI: 10.1177/0022034509337114
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