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Journal of Dental Research
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Biological

CTGF and Apoptosis in Mouse Osteocytes Induced by Tooth Movement

Y. Sakai1, T.A. Balam2, S. Kuroda2, N. Tamamura2, T. Fukunaga3, M. Takigawa4 and T. Takano-Yamamoto1,2,*

1 Division of Orthodontics and Dentofacial Orthopedics, Graduate School of Dentistry, Tohoku University, 4-1 Seiryo-cho, Aoba-ku, Sendai-city 980-8575, Japan;
2 Department of Orthodontics and Dentofacial Orthopedics, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University;
3 Department of Orthodontics, Graduate School of Medicine and Dentistry Sciences, Kagoshima University; and
4 Department of Biochemistry and Molecular Dentistry, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University

Correspondence: t-yamamo{at}mail.tains.tohoku.ac.jp

It is known that experimental tooth movement stimulates the gene expression of connective tissue growth factor (CTGF) and induces apoptosis in osteocytes in rats. We hypothesized that there is a relationship between CTGF expression and the induction of apoptosis in osteocytes, to play a significant role in triggering bone remodeling during experimental tooth movement. In this study, CTGF mRNA expression was detected at 2 hours in osteocytes on the pressure side, followed by apoptosis at 6 hours after tooth movement in mice. The number of empty lacunae significantly increased on day 1 after mechanical stimulation. Thereafter, the number of osteoclasts significantly increased on the pressure side of the alveolar bone on day 3. Tooth movement increased rapidly on day 10. These findings suggest that CTGF expression, followed by apoptosis in osteocytes in response to mechanical stimulation, might play a significant role in triggering bone remodeling during tooth movement.

Key Words: connective tissue growth factor (CTGF) • mechanical stimulation • osteocyte • apoptosis • in situ hybridization

Journal of Dental Research, Vol. 88, No. 4, 345-350 (2009)
DOI: 10.1177/0022034509334649
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