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Journal of Dental Research
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Biological

Adult Rat Odontoblasts Lack Noxious Thermal Sensitivity

K.Y. Yeon1,+, G. Chung1,+, M.S. Shin1, S.J. Jung2, J.S. Kim1 and S.B. Oh1,*

1 National Research Laboratory for Pain, Dental Research Institute and Department of Physiology, School of Dentistry, Seoul National University, 28-2 Yeongeon-Dong Chongno-Ku, Seoul 110-749, Korea; and
2 Department of Physiology, College of Medicine, Kangwon National Universtiy, Chunchon 200-710, Korea

Correspondence: odolbae{at}snu.ac.kr

Dentin hypersensitivity is a common symptom treated in the dental clinic, yet the underlying cellular and molecular mechanisms are not clear. We hypothesized that odontoblasts detect noxious thermal stimuli by expressing temperature-sensing molecules, and investigated whether temperature-activated TRP channels (thermo-TRP channels), which are known to initiate temperature signaling, mediate temperature sensing in odontoblasts. mRNA expression of dentin sialophosphoprotein and collagenase type 1, odontoblast-specific proteins, was shown in acutely isolated adult rat odontoblasts by single-cell RT-PCR, while TRPV1, TRPV2, TRPM8, and TRPA1 were not detected. Application of noxious temperatures of 42°C and 12°C, as well as capsaicin, menthol, and icilin, agonists of thermo-TRP channels, failed to increase intracellular calcium concentration. Immunohistochemical study also revealed no expression of TRPV1. Thus, it is unlikely that odontoblasts serve as thermal sensors in teeth via thermo-TRP channels.

Key Words: odontoblast • TRP • dentin hypersensitivity

Journal of Dental Research, Vol. 88, No. 4, 328-332 (2009)
DOI: 10.1177/0022034509334100
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