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Human Papillomavirus and Head and Neck Squamous Cell Carcinoma: Recent Evidence and Clinical Implications

¹ Department of Otolaryngology-Head and Neck Surgery and
² Department of Pathology, Johns Hopkins Medical Institutions, 601 N. Caroline Street, 6th Floor, Baltimore, MD 21287-0910, USA; and
³ Milton J. Dance Head and Neck Center, Greater Baltimore Medical Center, Baltimore, MD 21205, USA

Correspondence: jcalifa{at}jhmi.edu

Over the past 20 years, high-risk human papilloma-virus (HPV) infection has been established as a risk factor for developing head and neck squamous cell carcinoma, independent of tobacco and alcohol use. In particular, HPV is strongly associated with the development of oropharyngeal cancer and a small minority of oral cavity cancers. In this review, we summarize what is currently known about the biology of HPV, the mechanisms by which it effects malignant transformation, and the potential impact of HPV status on the clinical management of persons with head and neck cancer.

Key Words: HPV • oral cancer • oropharyngeal cancer

Journal of Dental Research, Vol. 88, No. 4, 300-306 (2009)
DOI: 10.1177/0022034509333371


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