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Journal of Dental Research
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Biological

Stem Cells from Deciduous Tooth Repair Mandibular Defect in Swine

Y. Zheng1, Y. Liu1, C.M. Zhang1, H.Y. Zhang2, W.H. Li2, S. Shi3, A.D. Le3,* and S.L. Wang1,4,*

1 Salivary Gland Disease Center and the Molecular Laboratory for Gene Therapy & Tooth Regeneration, Capital Medical University School of Stomatology, Tian Tan Xi Li No. 4, Beijing 100050, China;
2 Department of Cell Biology, Municipal Laboratory for Liver Protection and Regulation of Regeneration, Capital Medical University School of Basic Medical Sciences, You An Men Wai No.10, Beijing 100069, China;
3 The Center for Craniofacial Molecular Biology, University of Southern California School of Dentistry, 2250 Alcazar Street, CSA 103, Los Angeles, CA 90033, USA; and
4 Department of Biochemistry and Molecular Biology, Capital Medical University School of Basic Medical Sciences, You An Men Wai No.10, Beijing 100069, China

Correspondence: slwang{at}ccmu.edu.cn and anhle{at}usc.edu

Stem cells from human exfoliated deciduous teeth have been identified as a new post-natal stem cell population with multipotential differentiation capabilities, including regeneration of mineralized tissues in vivo. To examine the efficacy of utilizing these stem cells in regenerating orofacial bone defects, we isolated stem cells from miniature pig deciduous teeth and engrafted the critical-size bone defects generated in swine mandible models. Our results indicated that stem cells from miniature pig deciduous teeth, an autologous and easily accessible stem cell source, were able to engraft and regenerate bone to repair critical-size mandibular defects at 6 months post-surgical reconstruction. This pre-clinical study in a large-animal model, specifically swine, allows for testing of a stem cells/scaffold construct in the restoration of orofacial skeletal defects and provides rapid translation of stem-cell-based therapy in orofacial reconstruction in human clinical trials.

Key Words: deciduous tooth • stem cell • bone • tissue engineering • miniature pig

Journal of Dental Research, Vol. 88, No. 3, 249-254 (2009)
DOI: 10.1177/0022034509333804
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