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Genetic Risk Factors for Periodontitis in a Japanese Population

¹ General Dentistry and Clinical Education Unit, Niigata University Medical and Dental Hospital, 2-5274 Gakkocho-dori, Chuo-ku, Niigata 951-8514, Japan;
² Department of Periodontology and Endodontology, Oral and Maxillofacial Dentistry, Division of Medico-Dental Dynamics and Reconstruction, Institute of Health Biosciences, University of Tokushima Graduate School, Japan;
³ Department of Periodontology, Division of Oral Biology and Disease Control, Osaka University Graduate School of Dentistry, Japan;
⁴ Department of Pathophysiology-Periodontal Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Japan;
⁵ Department of Periodontal Medicine, Division of Frontier Medical Science, Hiroshima University Graduate School of Biomedical Science, Japan;
⁶ Section of Periodontology, Department of Hard Tissue Engineering, Tokyo Medical and Dental University Graduate School Japan;
⁷ Department of Periodontology, The Nippon Dental University School of Life Dentistry at Tokyo, Japan;
⁸ Health Technology Research Center, National Institute of Advanced Industrial Science and Technology, Japan;
⁹ Department of Periodontology, Fukuoka Dental College, Japan;
¹⁰ Division of Periodontology, Department of Oral Biology and Tissue Engineering, Meikai University School of Dentistry, Japan;
¹¹ Department of Pathology, Hyogo College of Medicine, Japan;
¹² Department of Periodontology, Showa University School of Dentistry, Japan; and
¹³ Division of Periodontology, Department of Oral Biological Science, Niigata University Graduate School of Medical and Dental Sciences, Japan

Correspondence: ^* kotetsuo{at}dent.niigata-u.ac.jp

Genetic variants at multiple loci have been shown to be associated with susceptibility to periodontitis. To better assess the genetic risk factors for periodontitis, we performed a case-control study in 319 Japanese individuals with periodontitis (172 aggressive and 147 chronic disease) and 303 race-matched healthy control individuals. Thirty-five functional gene polymorphisms that had been previously associated with immune responses were genotyped. For all gene polymorphisms tested, no significant differences were observed in the allele frequencies of persons with aggressive, chronic, and combined (aggressive and chronic) periodontitis, compared with control individuals. Multiple logistic regression analysis revealed a significant association of the vitamin D receptor +1056 T/C polymorphism with susceptibility to chronic periodontitis, after adjustment for age, gender, and smoking status (P = 0.002). These results suggest that none of the polymorphisms tested was strongly associated with periodontitis in a Japanese population. However, the vitamin D receptor +1056 polymorphism may be related to chronic periodontitis.

Key Words: genetic risk factor • periodontitis • Japanese

This version was published on December 1, 2009

Journal of Dental Research, Vol. 88, No. 12, 1137-1141 (2009)
DOI: 10.1177/0022034509350037


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