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Bacterial Interactions in Dental Biofilm Development

¹ Food Science Institute, Meiji Dairies Co., 540 Naruda, Odawara, Kanagawa 250-0862, Japan; and
² Department of Oral Bacteriology, Tsurumi University, Yokohama, Japan

Correspondence: ^* kenichi_houjou{at}meiji-milk.com

Recent analyses with ribosomal RNA-based technologies have revealed the diversity of bacterial populations within dental biofilms, and have highlighted their important contributions to oral health and disease. Dental biofilms are exceedingly complex and multispecies ecosystems, where oral bacteria interact cooperatively or competitively with other members. Bacterial interactions that influence dental biofilm communities include various different mechanisms. During the early stage of biofilm formation, it is known that planktonic bacterial cells directly attach to surfaces of the oral cavity or indirectly bind to other bacterial cells that have already colonized. Adherence through co-aggregation may be critical for the temporary retention of bacteria on dental surfaces, and may facilitate eventual bacterial colonization. It is likely that metabolic communication, genetic exchange, production of inhibitory factors (e.g., bacteriocins, hydrogen peroxide, etc.), and quorum-sensing are pivotal regulatory factors that determine the bacterial composition and/or metabolism. Since each bacterium can easily access a neighboring bacterial cell and its metabolites, genetic exchanges and metabolic communication may occur frequently in dental biofilms. Quorum-sensing is defined as gene regulation in response to cell density, which influences various functions, e.g., virulence and bacteriocin production. In this review, we discuss these important interactions among oral bacteria within the dental biofilm communities.

Key Words: dental plaque • biofilm formation • synergism • antagonism • metabolic communication • quorum-sensing • bacterial adherence • bacterial aggregation

Journal of Dental Research, Vol. 88, No. 11, 982-990 (2009)
DOI: 10.1177/0022034509346811


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