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Influence of Genetic Background on Fluoride Metabolism in Mice

¹ Department of Biological Sciences, Bauru Dental School, University of São Paulo, Al. Octávio Pinheiro Brisolla, 9-75, Bauru—SP 17012-901, São Paulo, Brazil;
² Dental Research, University of North Carolina, Chapel Hill, NC, USA;
³ Department of Pediatric Dentistry and The Carolina Center for Genome Sciences, University of North Carolina, Chapel Hill, NC, USA; and
⁴ Department of Oral Biology and Maxillofacial Pathology, Medical College of Georgia, Augusta, GA, USA

Correspondence: ^* mbuzalaf{at}fob.usp.br

A/J and 129P3/J mouse strains have different susceptibilities to dental fluorosis, due to their genetic backgrounds. This study tested whether these differences are due to variations in water intake and/or F metabolism. A/J (susceptible to dental fluorosis) and 129P3/J mice (resistant) received drinking water containing 0, 10, or 50 ppm F. Weekly F intake, excretion and retention, and terminal plasma and femur F levels were determined. Dental fluorosis was evaluated clinically and by quantitative fluorescence (QF). Data were tested by two-way ANOVA. Although F intakes by the strains were similar, excretion by A/J mice was significantly higher due to greater urinary F excretion, which resulted in lower plasma and femur F levels. Compared with 129P3/J mice given 50 ppm F, significantly higher QF scores were recorded for A/J mice. In conclusion, these strains differ with respect to several features of F metabolism, and amelogenesis in the 129P3/J strain seems to be unaffected by high F exposure.

Key Words: dental fluorosis • fluoride metabolism • genetic susceptibility/resistance • inbred mouse strains • bone

Journal of Dental Research, Vol. 88, No. 11, 1054-1058 (2009)
DOI: 10.1177/0022034509347249


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