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Journal of Dental Research
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BIOLOGICAL

CCR5 Down-regulates Osteoclast Function in Orthodontic Tooth Movement

I. Andrade, Jr.1,2,*, S.R.A. Taddei2, G.P. Garlet3, T.P. Garlet4, A.L. Teixeira2,5, T.A. Silva2,6 and M.M. Teixeira2

1 Department of Orthodontics, Faculty of Dentistry, Pontifícia Universidade Católica de Minas Gerais (PUC-Minas), Av. Dom José Gaspar 500, CEP 31.270-901, Belo Horizonte, Minas Gerais, Brazil;
2 Immunopharmacology, Department of Biochemistry and Immunology, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil;
3 Department of Biological Sciences, School of Dentistry of Bauru, São Paulo University, Bauru, São Paulo, Brazil;
4 Department of Pharmacology, School of Medicine of Ribeirão Preto, São Paulo University, Bauru, São Paulo, Brazil;
5 Department of Clinical Medicine, Faculty of Medicine, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil; and
6 Department of Oral Pathology, Faculty of Dentistry, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil

Correspondence: * ildeu_andrade{at}yahoo.com.br

During orthodontic tooth movement, there is local production of chemokines and an influx of leukocytes into the periodontium. CCL5 plays an important role in osteoclast recruitment and activation. This study aimed to investigate whether the CCR5-receptor influences these events and, consequently, orthodontic tooth movement. An orthodontic appliance was placed in wild-type mice (WT) and CCR5-deficient mice (CCR5–/–). The expression of mediators involved in bone remodeling was evaluated in periodontal tissues by Real-time PCR. The number of TRAP-positive osteoclasts and the expression of cathepsin K, RANKL, and MMP13 were significantly higher in CCR5–/–. Meanwhile, the expression of two osteoblastic differentiation markers, RUNX2 and osteocalcin, and that of bone resorption regulators, IL-10 and OPG, were lower in CCR5–/–. Analysis of the data also showed that CCR5–/– exhibited a greater amount of tooth movement after 7 days of mechanical loading. The results suggested that CCR5 might be a down-regulator of alveolar bone resorption during orthodontic movement.

Key Words: orthodontic tooth movement • bone remodeling • CCR5 • chemokines

Journal of Dental Research, Vol. 88, No. 11, 1037-1041 (2009)
DOI: 10.1177/0022034509346230
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