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Journal of Dental Research
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CRITICAL REVIEWS IN ORAL BIOLOGY & MEDICINE

Sensitivity of Salivary Glands to Radiation: from Animal Models to Therapies

O. Grundmann1,3, G.C. Mitchell2,3 and K.H. Limesand1,2,3,*

1 Department of Nutritional Sciences and
2 Cancer Biology Program, University of Arizona, 1177 E 4th St., Shantz 421, PO Box 210038, Tucson, AZ 85721, USA

Correspondence: * limesank{at}u.arizona.edu

Radiation therapy for head and neck cancer causes significant secondary side-effects in normal salivary glands, resulting in diminished quality of life for these individuals. Salivary glands are exquisitely sensitive to radiation and display acute and chronic responses to radiotherapy. This review will discuss clinical implications of radiosensitivity in normal salivary glands, compare animal models used to investigate radiation-induced salivary gland damage, address therapeutic advances, and project future directions in the field.

Key Words: radiation • salivary gland dysfunction • salivary glands • animal models • therapy • xerostomia

Journal of Dental Research, Vol. 88, No. 10, 894-903 (2009)
DOI: 10.1177/0022034509343143
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