Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

Click here to sign up for SAGE Journal Email Alerts today!

Sign In to gain access to subscriptions and/or personal tools.
Journal of Dental Research
This Article
Right arrow Figures Only
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Data Supplement
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Right arrow Citing Articles via Scopus
Google Scholar
Right arrow Articles by Chang, H.-H.
Right arrow Articles by Yao, C.-C.J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Chang, H.-H.
Right arrow Articles by Yao, C.-C.J.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Biological

MMP-3 Response to Compressive Forces in vitro and in vivo

H.-H. Chang1,2, C.-B. Wu3, Y.-J. Chen1,2, C.-Y. Weng1, W.-P. Wong1,2, Y.-J. Chen1,2, B.-E. Chang4, M.-H. Chen1,2 and C.-C.J. Yao1,2,4,*

1 School of Dentistry, National Taiwan University, Taiwan;
2 Dental Department, National Taiwan University Hospital, Taiwan;
3 Department of Orthodontics, Chang-Gung Memorial Hospital, and College of Medicine, Chang-Gung University; and
4 Graduate Institute of Oral Biology, National Taiwan University, 1 Chang-Te Street, Taipei 100, Taiwan

Correspondence: * corresponding author, janeyao{at}ntu.edu.tw

During orthodontic tooth movement, bone resorption occurs at the compression site. However, the mechanism underlying resorption remains unclear. Applying compressive force to human osteoblast-like cells grown in a 3D collagen gel, we examined gene induction by using microarray and RT-PCR analysis. Among 43 genes exhibiting significant changes, cyclo-oxygenase-2, ornithine decarboxylase, and matrix metalloproteinase-3 (MMP-3) were up-regulated, whereas membrane-bound interleukin-1 receptor accessory protein was down-regulated. The MMP-3 protein increases were further confirmed by Western blot. To ascertain whether MMP-3 is up-regulated in vivo by orthodontic force, we examined human bone samples at the compressive site by realigning the angulated molars. Immunohistochemical staining revealed MMP-3 distributed along the compressive site of the bony region within 3 days of compression. Since MMP-3 participates in degradation of a wide range of extracellular matrix molecules, we propose that MMP-3 plays an important role in bone resorption during orthodontic tooth movement.

Key Words: MMP • compressive force • osteoblasts • tooth movement

Journal of Dental Research, Vol. 87, No. 7, 692-696 (2008)
DOI: 10.1177/154405910808700714
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?


This article has been cited by other articles:


Home page
 J. Biol. Chem.Home page
C.-M. Yang, H.-L. Hsieh, C.-C. Yao, L.-D. Hsiao, C.-P. Tseng, and C. B. Wu
Protein Kinase C-{delta} Transactivates Platelet-derived Growth Factor Receptor-{alpha} in Mechanical Strain-induced Collagenase 3 (Matrix Metalloproteinase-13) Expression by Osteoblast-like Cells
J. Biol. Chem., September 18, 2009; 284(38): 26040 - 26050.
[Abstract] [Full Text] [PDF]