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Journal of Dental Research
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Biological

An Anti-c-Fms Antibody Inhibits Orthodontic Tooth Movement

H. Kitaura1,*, M. Yoshimatsu1, Y. Fujimura1, T. Eguchi1, H. Kohara1, A. Yamaguchi2 and N. Yoshida1

1 Divisions of Orthodontic and Dentofacial Orthopedics, Department of Translational Medicine, Course of Medical and Dental Sciences, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki 852-8588, Japan; and
2 Department of Oral Restitution, Section of Oral Pathology, Graduate School of Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8549, Japan

Correspondence: * corresponding author, kitaura{at}nagasaki-u.ac.jp

Orthodontic force induces osteoclastogenesis in vivo. It has recently been reported that administration of an antibody against the macrophage-colony-stimulating factor (M-CSF) receptor c-Fms blocks osteoclastogenesis and bone erosion induced by tumor necrosis factor-{alpha} (TNF-{alpha}) administration. This study aimed to examine the effect of an anti-c-Fms antibody on mechanical loading-induced osteoclastogenesis and osteolysis in an orthodontic tooth movement model in mice. Using TNF receptor 1- and 2-deficient mice, we showed that orthodontic tooth movement was mediated by TNF-{alpha}. We injected anti-c-Fms antibody daily into a local site, for 12 days, during mechanical loading. The anti-c-Fms antibody significantly inhibited orthodontic tooth movement, markedly reduced the number of osteoclasts in vivo, and inhibited TNF-{alpha}-induced osteoclastogenesis in vitro. These findings suggest that M-CSF plays an important role in mechanical loading-induced osteoclastogenesis and bone resorption during orthodontic tooth movement mediated by TNF-{alpha}.

Key Words: c-fms • osteoclast • orthodontics • mouse • TNF-{alpha}

Journal of Dental Research, Vol. 87, No. 4, 396-400 (2008)
DOI: 10.1177/154405910808700405
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