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Journal of Dental Research
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Biological

Effects of IL-17 on Human Gingival Fibroblasts

R. Mahanonda1,2,*, P. Jitprasertwong1, N. Sa-Ard-Iam2,3, P. Rerkyen2,3, O. Charatkulangkun1,2, P. Jansisyanont4, K. Nisapakultorn1,2, K. Yongvanichit5 and S. Pichyangkul5

1 Department of Periodontology,
2 Research Unit for Periodontal Disease,
3 Immunology Laboratory, and
4 Department of Oral Maxillofacial Surgery, Faculty of Dentistry, Chulalongkorn University, Henri Dunant Rd., Bangkok 10330, Thailand; and
5 Department of Immunology and Medicine, US Army Medical Component, Armed Forces Research Institute of Medical Sciences (AFRIMS), Bangkok, Thailand

Correspondence: * corresponding author, mrangsin{at}chula.ac.th

Interleukin (IL)-17 is present in inflammatory periodontal lesions, thus suggesting a role in mediating inflammation. We tested the hypothesis that IL-17, especially when combined with interferon (IFN)-{gamma}, may modulate the responses of human gingival fibroblasts (HGFs). IL-17 induced IL-8 and minimal intercellular adhesion molecule (ICAM)-1 expression. It had no effect on expression of HLA-DR, CD40, or the immune-suppressive enzyme indoleamine 2,3-dioxygenase (IDO). The effects of IL-17 on HGFs were compared with those of IFN-{gamma}. Unlike IL-17, IFN-{gamma} augmented the expression of HLA-DR, ICAM-1, and IDO, but not IL-8. Thus, IL-17 and IFN-{gamma} induce different HGF responses when administered separately. Interestingly, when IL-17 and IFN-{gamma} were combined, marked enhancement of ICAM-1, IL-8, and IDO expression by HGFs was observed. These findings suggest that IL-17, especially when combined with IFN-{gamma}, could play an important role in immune modulation through stimulation of HGFs in periodontal disease.

Key Words: human gingival fibroblasts • IL-17 • IFN-{gamma} • IL-8 • IDO

Abbreviations: Interleukin (IL) • T-helper (Th) • human gingival fibroblasts (HGFs) • indoleamine 2,3-dioxygenase (IDO) • monoclonal antibodies (mAbs) • intercellular adhesion molecule (ICAM)-1 • interferon (IFN)- {gamma} • tumor necrosis factor (TNF)- {gamma} • mean fluorescence intensity (MFI)

Journal of Dental Research, Vol. 87, No. 3, 267-272 (2008)
DOI: 10.1177/154405910808700314
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