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Journal of Dental Research
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Biomaterials & Bioengineering

Effects of Fluoride Dentifrices on Enamel Lesion Formation

S. Toda1 and J.D. Featherstone2,*

1 Division of Oral Health, Department of Health Science, Kanagawa Dental College, Japan; and
2 Department of Preventive and Restorative Dental Sciences, University of California San Francisco, Box 0758, 707 Parnassus Ave., San Francisco, CA 94143-0758, USA

Correspondence: * corresponding author, jdbf{at}ucsf.edu

An in vitro pH cycling model was used to test the hypothesis that the effects of 3 different fluoride compounds on de/remineralization are a function of the free fluoride ion concentration. Groups of 10 human enamel specimens were treated with one of: (a) amine fluoride (AmF), 1250 ppm F; (b) sodium monofluorophosphate (NaMFP), 1000 ppm F; (c) sodium fluoride (NaF), 1100 ppm F; (d) NaF, 250 ppm F; (e) Placebo (< 1 ppm F) dentifrices; or with aqueous solutions (f) NaF 900 ppm F or (g) NaF 30 ppm F. Lesions were assessed by cross-sectional microhardness. Mean ± SEM {Delta}Z (vol.% x µm) values of 3 dentifrices were: (a) 344 ± 155, (b) 4259 ± 257, and (c) 591 ± 83. The AmF (1250 ppm F) was not statistically significantly different from the NaF (1100 ppm F) dentifrice in this model. The NaMFP (1000 ppm F) dentifrice, without hydrolysis, had only the same efficacy as the NaF (30 ppm F) aqueous solution.

Key Words: fluoride dentifrice • pH cycling • dental enamel • in vitro study

Journal of Dental Research, Vol. 87, No. 3, 224-227 (2008)
DOI: 10.1177/154405910808700303
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