Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

CiteULike is a free service for managing and discovering scholarly references - click here to get started.

Sign In to gain access to subscriptions and/or personal tools.
Journal of Dental Research
This Article
Right arrow Figures Only
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Right arrow Citing Articles via Scopus
Google Scholar
Right arrow Articles by Luan, Q.
Right arrow Articles by Graves, D.T.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Luan, Q.
Right arrow Articles by Graves, D.T.
Right arrowPubmed/NCBI databases
*Compound via MeSH
*Substance via MeSH
Medline Plus Health Information
*Antibiotics
Hazardous Substances DB
*DIETHYLENE GLYCOL MONOETHYL ETHER
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Biological

Inhibition of Experimental Periodontitis by a Topical Boron-based Antimicrobial

Q. Luan1,3, T. Desta1, L. Chehab1, V.J. Sanders2, J. Plattner2 and D.T. Graves*,1

1 Department of Periodontology and Oral Biology, Boston University School of Dental Medicine, Boston, MA 02118, USA;
2 Anacor Pharmaceuticals, Inc., Palo Alto, CA 94303, USA;
3 Department of Periodontology, Peking University School of Stomatology, Beijing, China 100081

Correspondence: * corresponding author, dgraves{at}bu.edu

AN0128 is a boron-containing compound with antibacterial and anti-inflammatory properties. To test its potential effectiveness in treating periodontal disease, we induced experimental periodontitis in the rat by placing ligatures and assessed the impact of AN0128 and positive and negative controls by micro-CT and histologic measurements. The formation of an inflammatory infiltrate was measured in hematoxylin-and-eosin-stained sections. Daily application of AN0128 (1%) compared with controls reduced bone loss by 38 to 44% (P < 0.05), while vehicle alone had no effect (P > 0.05). The reduction in bone loss with AN0128 was similar to that achieved with a NSAID, ketorolac, and Total toothpaste containing triclosan. AN0128 also reduced the level of gingival inflammation 42% compared with the ligature only (P < 0.05), whereas vehicle alone had no effect (P > 0.05). The results indicate that AN0128 significantly reduces the formation of an inflammatory infiltrate and reduces bone loss, measured histologically and by micro-CT.

Key Words: alveolar bone • antibiotic • antibacterial • boron • inflammation • micro-CT • periodontium • rat

Journal of Dental Research, Vol. 87, No. 2, 148-152 (2008)
DOI: 10.1177/154405910808700208
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?


This article has been cited by other articles:


Home page
 Infect. Immun.Home page
H. Kuula, T. Salo, E. Pirila, A. M. Tuomainen, M. Jauhiainen, V.-J. Uitto, L. Tjaderhane, P. J. Pussinen, and T. Sorsa
Local and Systemic Responses in Matrix Metalloproteinase 8-Deficient Mice during Porphyromonas gingivalis-Induced Periodontitis
Infect. Immun., February 1, 2009; 77(2): 850 - 859.
[Abstract] [Full Text] [PDF]