Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

CiteULike is a free service for managing and discovering scholarly references - click here to get started.

Sign In to gain access to subscriptions and/or personal tools.
Journal of Dental Research
This Article
Right arrow Figures Only
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Right arrow Citing Articles via Scopus
Google Scholar
Right arrow Articles by Fukada, S.Y.
Right arrow Articles by Cunha, F.Q.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Fukada, S.Y.
Right arrow Articles by Cunha, F.Q.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Biological

iNOS -derived Nitric Oxide Modulates Infection-stimulated Bone Loss

S.Y. Fukada1, T.A. Silva2, I.F. Saconato1, G.P. Garlet3, M.J. Ávila-Campos4, J.S. Silva5 and F.Q. Cunha1,*

1 Department of Pharmacology, School of Medicine of Ribeirão Preto, University of São Paulo, Av. Bandeirantes 3900, Monte Alegre, 14049-900, Ribeirão Preto SP, São Paulo, Brazil;
2 Department of Oral Surgery and Pathology, School of Dentistry, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil;
3 Department of Biological Sciences, School of Dentistry of Bauru, University of São Paulo, Bauru, São Paulo, Brazil;
4 Department of Microbiology, Institute of Biomedical Sciences, University of Sao Paulo, São Paulo, Brazil; and
5 Department of Biochemistry and Immunology, School of Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto, São Paulo, Brazil

Correspondence: * corresponding author, fdqcunha{at}fmrp.usp.br

Nitric oxide (NO) derived from inducible nitric oxide synthase (iNOS) plays an important role in host defense, as well as in inflammation-induced tissue lesions. Here we evaluated the role of NO in bone loss in bacterial infection-induced apical periodontitis by using iNOS-deficient mice (iNOS–/–). The iNOS–/– mice developed greater inflammatory cell recruitment and osteolytic lesions than WT mice. Moreover, tartrate-resistant acid-phosphatase-positive (TRAP+) osteoclasts were significantly more numerous in iNOS–/– mice. Furthermore, the increased bone resorption in iNOS–/– mice also correlated with the increased expression of receptor activator NF-kappaB (RANK), stromal-cell-derived factor-1{alpha} (SDF-1{alpha}/CXCL12), and reduced expression of osteoprotegerin (OPG). These results show that NO deficiency was associated with an imbalance of bone-resorption-modulating factors, leading to severe infection-stimulated bone loss.

Key Words: Nitric oxide • osteoclastogenesis • RANK • RANKL • OPG • SDF-1{alpha}/CXCL12

Journal of Dental Research, Vol. 87, No. 12, 1155-1159 (2008)
DOI: 10.1177/154405910808701207
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?


This article has been cited by other articles:


Home page
 Proc. Natl. Acad. Sci. USAHome page
Q. Zhou, S. E. Leeman, and S. Amar
Signaling mechanisms involved in altered function of macrophages from diet-induced obese mice affect immune responses
PNAS, June 30, 2009; 106(26): 10740 - 10745.
[Abstract] [Full Text] [PDF]