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Journal of Dental Research
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Biological

Association between High miR-211 microRNA Expression and the Poor Prognosis of Oral Carcinoma

K.-W. Chang1,#, C.-J. Liu1,2,3,#, T.-H. Chu1, H.-W. Cheng2, P.-S. Hung1, W.-Y. Hu4 and S.-C. Lin1,*

1 Institute of Oral Biology, School of Dentistry, National Yang-Ming University, No. 155, Li-Nong St., Sec.2, Taipei, Taiwan 112;
2 Department of Oral and Maxillofacial Surgery, Taipei MacKay Memorial Hospital, Taipei, Taiwan;
3 MacKay Medicine, Nursing and Management College, Taipei, Taiwan; and
4 Biosettia, San Diego, CA, USA

Correspondence: * corresponding author, sclin{at}ym.edu.tw

MicroRNAs (miRNAs) are non-coding RNAs that play roles in gene silencing and may be involved in tumorigenesis. miR-211 was mapped to chromosome 15q13, a locus frequently altered in cancers. The role of miR-211in carcinogenesis has not been clearly defined, however. This study investigated the pathogenetic implications of miR-211 in oral carcinogenesis. An association was found between higher miR-211 expression and the most advanced nodal metastasis, vascular invasion, and poor prognosis of oral carcinoma. The function of enforced miR-211 expression in oral carcinoma cells was confirmed by the repression of LacZ in a reporter plasmid via miR-211 targeting. Enforced miR-211 expression significantly increased the proliferation, migration, and anchorage-independent colony formation of oral carcinoma cells, while it enhanced the tumorigenicity of only SAS high-grade oral carcinoma cells, but not OECM-1 non-tumorigenic cells. The findings suggest that high miR-211 expression may be associated with the progression of oral carcinoma and poor patient outcomes.

Key Words: lentivirus • microRNA • miR-211 • oral carcinoma

Abbreviations: Ct, threshold cycle • EF1{alpha}, elongation factor 1{alpha} • HNSCC, head and neck squamous cell carcinoma • NHOK, normal human oral keratinocyte • OPL, oral precancerous lesion • OSCC, oral squamous cell carcinoma • Q-RT-PCR, quantitative reverse-transcriptase polymerase chain-reaction

Journal of Dental Research, Vol. 87, No. 11, 1063-1068 (2008)
DOI: 10.1177/154405910808701116
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