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Journal of Dental Research
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Clinical

Cathepsin C Gene Variants in Aggressive Periodontitis

B. Noack1,*, H. Görgens2, U. Hempel3, J. Fanghänel4, Th. Hoffmann1, A. Ziegler5 and H.K. Schackert2

1 Department of Conservative Dentistry,
2 Department of Surgical Research, and
3 Institute of Physiological Chemistry, Dresden University of Technology, Medical Faculty, Fetscherstrasse 74, 01307, Dresden, Germany;
4 Department of Periodontology, Ernst Moritz Arndt University, Greifswald, Germany; and
5 Institute of Medical Biometry and Statistics, University at Lübeck, Germany

Correspondence: * corresponding author, Barbara.Noack{at}uniklinikum-dresden.de

Cathepsin C (CTSC) mutations are known to cause Papillon-Lefèvre syndrome. The aim of this study was to examine the association of CTSC genotype with susceptibility to non-syndromic aggressive periodontitis. The CTSC gene was analyzed in 110 persons with generalized aggressive periodontitis in comparison with 78 control individuals, after identifying different variants in a cohort of 100 persons. Five out of 19 discovered variants were included in this association study, representing 5 single-nucleotide polymorphism groups in tight linkage disequilibrium. The relevance of genotypes on enzyme function was examined. The carrier frequency of the missense variant p.I453V was significantly increased in persons with disease compared with healthy control individuals (17.3% vs. 6.4%, p < 0.05). CTSC activity in leukocytes from individuals harboring this variant was significantly reduced (119.8 {Delta}OD/min*105 cells, 95% confidence interval 17.4–174.9, p = 0.018). No influence of promoter variants was found on mRNA expression. The results support the hypothesis that CTSC gene variants contribute to increased susceptibility in generalized aggressive periodontitis.

Key Words: aggressive periodontitis • Papillon-Lefèvre syndrome • genetic susceptibility • cathepsin C gene variants

Journal of Dental Research, Vol. 87, No. 10, 958-963 (2008)
DOI: 10.1177/154405910808701017
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