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Journal of Dental Research
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Clinical

Dentin in Severe Fluorosis: a Quantitative Histochemical Study

F. Rojas-Sánchez1, M. Alaminos2, A. Campos2, H. Rivera1 and M.C. Sánchez-Quevedo2,*

1 Instituto de Investigaciones Odontológicas Raúl Vincentelli, Facultad de Odontología, Universidad Central de Venezuela, Caracas, Venezuela; and
2 Departamento de Histología, Facultad de Medicina y Odontología, Universidad de Granada, E-18071 Granada, Spain

Correspondence: * corresponding author, mcsanchez{at}histolii.ugr.es

Dentin responds to different alterations in the enamel with hypermineralization, and is a biomarker of fluoride exposure. We hypothesized that severe fluorosis would lead to hypermineralization of the dentin when the enamel was severely affected. We used scanning electron microscopy and quantitative electron-probe microanalysis to compare dentin and enamel from healthy and fluorotic teeth. The dentin in fluorotic teeth was characterized by a highly mineralized sclerotic pattern, in comparison with control teeth (p < 0.001) and fluorotic enamel lesions (p < 0.001). Enamel near the lesions showed hypercalcification in comparison with dentin (p < 0.001). In response to the effects of severe fluorosis in the enamel, the dentin showed hypermineralization, as found in other enamel disorders. The hypermineralization response of the dentin in our samples suggests that the mechanism of the response should be taken into account in dental caries and other dental disorders associated with severe fluorosis.

Key Words: dentin • fluoride • mineralization • electron microscopy • x-ray microanalysis

Journal of Dental Research, Vol. 86, No. 9, 857-861 (2007)
DOI: 10.1177/154405910708600910
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