Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

CiteULike is a free service for managing and discovering scholarly references - click here to get started.

Sign In to gain access to subscriptions and/or personal tools.
Journal of Dental Research
This Article
Right arrow Figures Only
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Right arrow Citing Articles via Scopus
Google Scholar
Right arrow Articles by Maeda, A.
Right arrow Articles by Matsuguchi, T.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Maeda, A.
Right arrow Articles by Matsuguchi, T.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Biological

Force-induced IL-8 from Periodontal Ligament Cells Requires IL-1β

A. Maeda1, K. Soejima1, K. Bandow2, K. Kuroe1, K. Kakimoto2, S. Miyawaki1, A. Okamoto1 and T. Matsuguchi2,*

1 Department of Orthodontics, and
2 Department of Biochemistry and Molecular Dentistry, Field of Developmental Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, 8-35-1 Sakuragaoka, Kagoshima 890-8544, Japan

Correspondence: * corresponding author, tmatsugu{at}denta.hal.kagoshima-u.ac.jp

During orthodontic tooth movement, mechanical stresses induce inflammatory reactions in the periodontal ligament (PDL). We hypothesized that chemokines released from PDL cells under mechanical stress regulate osteoclastogenesis, and investigated the profiles and mechanisms of chemokine expression by human PDL cells in response to mechanical stress. In vitro, shear stress and pressure force rapidly increased the gene and protein expressions of IL-8/CXCL8 by PDL cells. Consistently, amounts of IL-8 in the gingival crevicular fluid of healthy individuals increased within 2 to 4 days of orthodontic force application. The PDL cells constitutively expressed low levels of IL-1β, which were not further increased by mechanical stress. Interestingly, neutralization of IL-1β abolished IL-8 induction by mechanical stresses, indicating that IL-1β is essential for IL-8 induction, presumably though autocrine or paracrine mechanisms. Finally, experiments with signal-specific inhibitors indicated that MAP kinase activation is essential for IL-8 induction.

Key Words: orthodontics • IL-8 • IL-1β • periodontal ligament cell • mechanical stress

Journal of Dental Research, Vol. 86, No. 7, 629-634 (2007)
DOI: 10.1177/154405910708600709
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?


This article has been cited by other articles:


Home page
 JDRHome page
I. Andrade Jr., S.R.A. Taddei, G.P. Garlet, T.P. Garlet, A.L. Teixeira, T.A. Silva, and M.M. Teixeira
CCR5 Down-regulates Osteoclast Function in Orthodontic Tooth Movement
Journal of Dental Research, November 1, 2009; 88(11): 1037 - 1041.
[Abstract] [Full Text] [PDF]

Home page
 JDRHome page
V. Krishnan and Z. Davidovitch
On a Path to Unfolding the Biological Mechanisms of Orthodontic Tooth Movement
Journal of Dental Research, July 1, 2009; 88(7): 597 - 608.
[Abstract] [Full Text] [PDF]