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Journal of Dental Research
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Biological

Nuclear Factor {kappa}B p65 Phosphorylation in Orthodontic Tooth Movement

J. Zuo, L.A. Archer, A. Cooper, K.L. Johnson, L.S. Holliday and C. Dolce*

Department of Orthodontics, 1600 SW Archer Road, Campus Box 100444, University of Florida College of Dentistry, Gainesville, FL 32610, USA

Correspondence: * corresponding author, cdolce{at}dental.ufl.edu

Osteoclasts play a vital role in orthodontic tooth movement. Transactivation of nuclear factor {kappa}B (NF{kappa}B) by phosphorylation of the p65 component of NF{kappa}B at amino acid 536 (p65*536) plays a role in osteoclast differentiation stimulated by receptor activator of nuclear factor {kappa}B-ligand (RANK-L). We hypothesized that this transactivation pathway might be involved in the responses of alveolar bone cells during orthodontic tooth movement. We detected sharp increases in the levels of p65*536 3 and 12 hrs after the application of orthodontic stimuli in rats. In cell culture, osteoclast-like cells displayed no changes in p65*536 in response to RANK-L, but levels rapidly increased after the cells were mechanically scraped. We conclude that p65*536 is produced rapidly in response to orthodontic stimuli and mechanical insults, and may be important in bone remodeling associated with orthodontic tooth movement.

Key Words: osteoclast • bone resorption • RANK • RAW 264.7 • osteoclastogenesis

Journal of Dental Research, Vol. 86, No. 6, 556-559 (2007)
DOI: 10.1177/154405910708600613
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