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Journal of Dental Research
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Clinical

Effectiveness of Fluoride in Preventing Caries in Adults

S.O. Griffin1,*, E. Regnier2, P.M. Griffin3 and V. Huntley1

1 Centers for Disease Control and Prevention/Division of Oral Health, 4770 Buford Highway, MSF10, Chamblee, GA 30341, USA;
2 Defense Resources Management Institute, Naval Postgraduate School, 699 Dyer Road, Monterey, CA 93943, USA; and
3 H. Milton Stewart School of Industrial and Systems Engineering, Georgia Institute of Technology, Atlanta, GA 30332-0205, USA;

Correspondence: * corresponding author, sig1{at}cdc.gov

To date, no systematic reviews have found fluoride to be effective in preventing dental caries in adults. The objective of this meta-analysis was to examine the effectiveness of self- and professionally applied fluoride and water fluoridation among adults. We used a random-effects model to estimate the effect size of fluoride (absolute difference in annual caries increment or relative risk ratio) for all adults aged 20+ years and for adults aged 40+ years. Twenty studies were included in the final body of evidence. Among studies published after/during 1980, any fluoride (self- and professionally applied or water fluoridation) annually averted 0.29 (95%CI: 0.16–0.42) carious coronal and 0.22 (95%CI: 0.08–0.37) carious root surfaces. The prevented fraction for water fluoridation was 27% (95%CI: 19%–34%). These findings suggest that fluoride prevents caries among adults of all ages.

Key Words: caries • fluoride • adults • meta-analysis

Journal of Dental Research, Vol. 86, No. 5, 410-415 (2007)
DOI: 10.1177/154405910708600504
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