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Journal of Dental Research
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Biological

A Genome Segment on Mouse Chromosome 12 Determines Maxillary Growth

J. Oh1, C.J. Wang2, M. Poole1, E. Kim1, R.C. Davis3, I. Nishimura2 and E.-K. Pae1,*

1 Section of Orthodontics, UCLA School of Dentistry, 43-091 Center for the Health Sciences, Box 951668, Los Angeles, CA 90095-1668, USA;
2 The Jane and Jerry Weintraub Center for Reconstructive Biotechnology, Division of Advanced Prosthodontics, Biomaterials and Hospital Dentistry, UCLA School of Dentistry; and
3 Cardiology Division, Department of Medicine, The David Geffen School of Medicine at UCLA

Correspondence: * corresponding author, epae{at}dentistry.ucla.edu

The primary and modifier genes that regulate normal maxillofacial development are unknown. Previous quantitative trait locus (QTL) analyses using the F2 progeny of 2 mouse strains, DBA/2J (short snout/wide face) and C57BL/6J (long snout/narrow face), revealed a significant logarithm-of-odds (LOD) score for snout length on mouse chromosome 12 at 44 centimorgan (cM). We further sought to validate this locus contributing to anterior-posterior dimensions of the upper mid-face at the D12Mit7 marker in a 44-centimorgan portion of chromosome 12. Congenic mice carrying introgressed DNA from DBA/2J on a C57BL/6J background were selected for submental vertex cephalometric imaging. Results confirmed QTLs, determining that short snout length (P < 0.05) and face width relative to snout length (P < 0.01) were present in the 44-cM region of chromosome 12. We conclude that one or more genes contributing to the shape of the maxillary complex are located near 44 cM of mouse chromosome 12.

Key Words: facial types • congenic mice • maxilla • quantitative trait loci (QTL)

Journal of Dental Research, Vol. 86, No. 12, 1203-1206 (2007)
DOI: 10.1177/154405910708601212
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