Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

Click here to sign up for SAGE Journal Email Alerts today!

Sign In to gain access to subscriptions and/or personal tools.
Journal of Dental Research
This Article
Right arrow Figures Only
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Right arrow Citing Articles via Scopus
Google Scholar
Right arrow Articles by Teughels, W.
Right arrow Articles by Quirynen, M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Teughels, W.
Right arrow Articles by Quirynen, M.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Biological

Guiding Periodontal Pocket Recolonization: a Proof of Concept

W. Teughels1,*, M.G. Newman2, W. Coucke1, A.D. Haffajee3, H.C. Van Der Mei4, S. Kinder Haake2, E. Schepers5, J.-J. Cassiman6, J. Van Eldere7, D. van Steenberghe1 and M. Quirynen1

1 Catholic University Leuven, Research Group for Microbial Adhesion, Department of Periodontology, Kapucijnenvoer 7, 3000 Leuven, Belgium;
2 UCLA, School of Dentistry, 10833 Le Conte Avenue, Los Angeles, CA, USA;
3 The Forsyth Institute, Department of Periodontics, 140 The Fenway, Boston, MA, USA;
4 University of Groningen, Department of Biomedical Engineering, Antonius Deusinglaan 1, 9713 AV Groningen, the Netherlands;
5 Catholic University Leuven, BioMat Research Cluster, Kapucijnenvoer 7, 3000 Leuven, Belgium;
6 Catholic University Leuven, Department of Human Genetics, Herestraat 49, 3000 Leuven, Belgium; and
7 Catholic University Leuven, Centre for Molecular Diagnostics, Herestraat 49, 3000 Leuven, Belgium

Correspondence: * corresponding author, Wim.Teughels{at}med.kuleuven.be

The complexity of the periodontal microbiota resembles that of the gastro-intestinal tract, where infectious diseases are treatable via probiotics. In the oropharyngeal region, probiotic or replacement therapies have shown some benefit in the prevention of dental caries, otitis media, and pharyngitis, but their effectiveness in the treatment of periodontitis is unknown. Therefore, this study addressed the hypothesis that the application of selected beneficial bacteria, as an adjunct to scaling and root planing, would inhibit the periodontopathogen recolonization of periodontal pockets. Analysis of the data showed, in a beagle dog model, that when beneficial bacteria were applied in periodontal pockets adjunctively after root planing, subgingival recolonization of periodontopathogens was delayed and reduced, as was the degree of inflammation, at a clinically significant level. The study confirmed the hypothesis and provides a proof of concept for a guided pocket recolonization (GPR) approach in the treatment of periodontitis.

Key Words: probiotics • periodontitis • therapy • microbial interference • replacement therapy • treatment

Journal of Dental Research, Vol. 86, No. 11, 1078-1082 (2007)
DOI: 10.1177/154405910708601111
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?


This article has been cited by other articles:


Home page
 J. Clin. Microbiol.Home page
B. Riep, L. Edesi-Neuss, F. Claessen, H. Skarabis, B. Ehmke, T. F. Flemmig, J.-P. Bernimoulin, U. B. Gobel, and A. Moter
Are Putative Periodontal Pathogens Reliable Diagnostic Markers?
J. Clin. Microbiol., June 1, 2009; 47(6): 1705 - 1711.
[Abstract] [Full Text] [PDF]