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Journal of Dental Research
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Biomaterials & Bioengineering

Effects of Hydrogen Peroxide on Human Dentin Structure

T. Jiang1,2, X. Ma1, Y. Wang1,*, Z. Zhu, H. Tong2 and J. Hu2,*

1 Key Laboratory for Oral Biomedical Engineering, Ministry of Education, School and Hospital of Stomatology, Wuhan University, Wuhan, PR China;
2 Institute of Analytical and Biomedical Science, Wuhan University, Wuhan 430072, PR China; and
3 College of Physical Science and Technology, HuaZhong Normal University, Wuhan, PR China

Correspondence: * corresponding authors, yiningwang{at}whuss.com and jmhu{at}whu.edu.cn

It has been hypothesized that hydrogen peroxide (H2O2) bleaching may cause destruction of dentin by a mechanism of protein oxidation. However, to our knowledge, there has been no direct chemical evidence to validate this viewpoint. To investigate the effects of H2O2 on the structure of human dentin, we used Fourier transform infrared spectroscopy (FTIR) and attenuated total reflection (ATR) spectroscopy. Human intact dentin specimens were treated either with 30% H2O2 or Hanks’ balanced salt solution (HBSS). Significant differences were observed in ATR spectra parameters. Additionally, demineralized dentin specimens were also tested. They were completely dissolved in the H2O2, but remained intact in the 0.1 N HCl and HBSS. The results suggested that H2O2 attacked both the organic and mineral components of dentin. Destruction of the organic components was mainly because of the oxidizing ability of H2O2, while changes in the mineral components were probably due to its acidity.

Key Words: dentin • hydrogen peroxide • FTIR • ATR

Journal of Dental Research, Vol. 86, No. 11, 1040-1045 (2007)
DOI: 10.1177/154405910708601104
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