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Journal of Dental Research
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Biological

PGE2 Activates Cementoclastogenesis by Cementoblasts via EP4

H. Oka1, M. Miyauchi1,*, K. Sakamoto1, S. Moriwaki2, S. Niida2, K. Noguchi3, M.J. Somerman4 and T. Takata1,*

1 Department of Oral and Maxillofacial Pathobiology, Graduate School of Biomedical Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8553, Japan;
2 Department of Bone and Joint Disease, Research Institute, National Center for Geriatrics and Gerontology, 36-3 Gengo, Obu, Aichi 474-8522, Japan;
3 Department of Periodontology, Graduate School of Medical and Dental Sciences, Kagoshima University, 8-35-1 Sakuragaoka, Kagoshima 890-8544, Japan; and
4 Department of Periodontics, School of Dentistry, 1959 NE Pacific, D322-Health Science Center, University of Washington, Seattle, WA 98195-7444, USA

Correspondence: * corresponding authors, mmiya{at}hiroshima-u.ac.jp and ttakata{at}hiroshima-u.ac.jp

Destruction of cementum and alveolar bone is the main causative event for the exfoliation of teeth as a consequence of periodontitis. Prostaglandin E2 (PGE2) and PGE receptor subtypes (EPs) play an important role in modulating osteoblast-mediated osteoclastogenesis; however, no information is available on the role of PGE2 and EPs in regulating cementoblast-mediated cementoclastogenesis. We hypothesized that the PGE2-EPs pathway also regulates cementoblasts’ ability to activate cementoclasts. For these studies, OCCM-30 cells (a mouse cementoblast cell line) were exposed to PGE2 and specific EP agonists. PGE2 (100 ng/mL) and EP4 agonist (1 µM) up-regulated RANKL and IL-6 mRNA levels, while they down-regulated OPG mRNA expression. The EP4 antagonist (1 µM) eliminated these effects of PGE2. PGE2 treatment of co-cultures of OCCM-30 cells with bone marrow cells induced TRAP-positive cells via the EP4 pathway. These findings suggest that PGE2 promotes cementoblast-mediated cementoclastogenesis by regulating the expression of RANKL and OPG via the EP4 pathway.

Key Words: prostaglandin E2 • PGE receptor subtypes • cementoblasts • periodontal tissue

Journal of Dental Research, Vol. 86, No. 10, 974-979 (2007)
DOI: 10.1177/154405910708601011
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