Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

Click here to sign up for SAGE Journal Email Alerts today!

Sign In to gain access to subscriptions and/or personal tools.
Journal of Dental Research
This Article
Right arrow Figures Only
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Right arrow Citing Articles via Scopus
Google Scholar
Right arrow Articles by Ford, P.J.
Right arrow Articles by Seymour, G.J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Ford, P.J.
Right arrow Articles by Seymour, G.J.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

Biological

Anti-P. gingivalis Response Correlates with Atherosclerosis

P.J. Ford1,*, E. Gemmell1, P. Timms2, A. Chan1, F.M. Preston1 and G.J. Seymour1

1 Oral Biology and Pathology, School of Dentistry, University of Queensland, Brisbane 4072, Australia; and
2 Infectious Diseases Program, Science Research Centre, School of Life Sciences, Queensland University of Technology, Brisbane 4001, Australia

Correspondence: * corresponding author, p.ford{at}uq.edu.au

Significant associations between atherosclerosis and both Porphyromonas gingivalis, a major periodontopathogen, and the respiratory pathogen, Chlamydia pneumoniae, have been shown. Many individuals with evidence of atherosclerosis demonstrate seropositivity to these pathogens. The aim of the present study was to examine the atherogenic effect of repeated immunizations with either or both of these agents, and to determine if molecular mimicry of bacterial heat-shock protein (HSP), termed GroEL, and host (h) HSP60 was involved. Atherogenesis was examined in apolipoprotein-E-deficient (–/–) mice following intraperitoneal immunizations with P. gingivalis, C. pneumoniae, P. gingivalis, and C. pneumoniae or vehicle. Lesion area in the proximal aorta and levels of serum antibodies to P. gingivalis, C. pneumoniae, and GroEL were measured. The increased pathogen burden of P. gingivalis, but not of C. pneumoniae, enhanced atherosclerosis. hHSP60 was detected in lesions, and in P. gingivalis-immunized mice, lesion development was correlated with anti-GroEL antibody levels, supporting the involvement of molecular mimicry between GroEL and hHSP60.

Key Words: Porphyromonas gingivalis • periodontal disease • antibody response • atherosclerosis • mouse model

Journal of Dental Research, Vol. 86, No. 1, 35-40 (2007)
DOI: 10.1177/154405910708600105
Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 Journal of the American Dental AssociationHome page
S. Kidambi and S. B. Patel
Diabetes Mellitus: Considerations for Dentistry
J Am Dent Assoc, October 1, 2008; 139(suppl_5): 8S - 18S.
[Abstract] [Full Text] [PDF]


Journal of Dental Research Call for Editor