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Journal of Dental Research
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Biological

Clodronate Inhibits PGE2 Production in Compressed Periodontal Ligament Cells

L. Liu1,4, K. Igarashi2,*, H. Kanzaki1, M. Chiba2, H. Shinoda3 and H. Mitani1

1 Divisions of Orthodontics and Dentofacial Orthopedics,
2 Oral Dysfunction Science, and
3 Dental Pharmacology, Tohoku University Graduate School of Dentistry, 4-1 Seiryo-machi, Aoba-ku, Sendai 980-8575, Japan

Correspondence: * corresponding author, igarashi{at}mail.tains.tohoku.ac.jp

Periodontal ligament (PDL) cells play an essential role in orthodontic tooth movement. We recently reported that clodronate, a non-N-containing bisphosphonate, strongly inhibited tooth movement in rats, and thus could be a useful adjunct for orthodontic treatment. However, it is not clear how clodronate affects the responses of PDL cells to orthodontic force. In this study, we hypothesized that clodronate prevents the mechanical stress-induced production of prostaglandin E2 (PGE2), interleukin-1β (IL-1β), and nitric oxide (NO) in human PDL cells. A compressive stimulus caused a striking increase in PGE2 production, while the responses of IL-1β and NO were less marked. Clodronate concentration-dependently inhibited the stress-induced production of PGE2. Clodronate also strongly inhibited stress-induced gene expression for COX-2 and RANKL. These results suggest that the inhibitory effects of clodronate on tooth movement and osteoclasts may be due, at least in part, to the inhibition of COX-2-dependent PGE2 production and RANKL expression in PDL cells.

Key Words: clodronate • periodontal ligament cell • mechanical stress • prostaglandin E2

Journal of Dental Research, Vol. 85, No. 8, 757-760 (2006)
DOI: 10.1177/154405910608500813
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