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Journal of Dental Research
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Clinical

Taste Loss and Recovery Following Radiation Therapy

P.L. Sandow*, M. Hejrat-Yazdi and M.W. Heft

Department of Oral & Maxillofacial Surgery and Diagnostic Sciences, University of Florida Health Science Center, 1600 SW Archer Road, Room D8-6, PO Box 100414, Gainesville, FL 32610-0414, USA

Correspondence: * corresponding author, psandow{at}dental.ufl.edu

Previous investigators have reported deficits in taste acuity in patients following radiation therapy for oropharyngeal cancer. In the present longitudinal study, 13 patients (mean age = 51.6 yrs) received conventional or hyperfractionated radiotherapy (63–76.8 Gy) for primary tumors of the oropharynx. One or both parotid glands and at least two-thirds of the tongue were included in the radiation field. Smell recognition and taste detection thresholds were determined at baseline, 1 month, 6 months, and 1 year post-radiation. Differences for smell recognition and the 4 taste qualities were assessed (independently) at the 4 time intervals, with a one-way ANOVA. Smell recognition was unaffected by radiation. There were significant elevations in thresholds for sweet (p < 0.005), salty (p < 0.005), bitter (p < 0.005), and sour (p< 0.001) during radiation therapy that were restored to baseline levels at 6 months and 1 year after radiation. This study demonstrated that radiation-induced taste deficits can be recovered by 6 months.

Key Words: radiation • dysgeusia • recovery • taste

Journal of Dental Research, Vol. 85, No. 7, 608-611 (2006)
DOI: 10.1177/154405910608500705
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