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Journal of Dental Research
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Biological

Inhibition of Apoptosis in Early Tooth Development Alters Tooth Shape and Size

J.-Y. Kim1, Y.-G. Cha1, S.-W. Cho, E.-J. Kim, M.-J. Lee, J.-M. Lee, J. Cai, H. Ohshima2 and H.-S. Jung*

Division in Anatomy and Developmental Biology, Department of Oral Biology, Research Center for Orofacial Hard Tissue Regeneration, Oral Science Research Center, College of Dentistry, Brain Korea 21 Project for Medical Science, Yonsei Center of Biotechnology, Yonsei University, 134 Shinchon-Dong, Seodaemoon-Gu, Seoul, 120-752, Korea; and
2 Division of Anatomy and Cell Biology of the Hard Tissue, Department of Tissue Regeneration and Reconstruction, Niigata University Graduate School of Medical and Dental Sciences, Japan

Correspondence: * corresponding author, hsjung{at}yumc.yonsei.ac.kr

Apoptosis plays important roles in various stages of organogenesis. In this study, we hypothesized that apoptosis would play an important role in tooth morphogenesis. We examined the role of apoptosis in early tooth development by using a caspase inhibitor, z-VAD-fmk, concomitant with in vitro organ culture and tooth germ transplantation into the kidney capsule. Inhibition of apoptosis at the early cap stage did not disrupt the cell proliferation level when compared with controls. However, the macroscopic morphology of mice molar teeth exhibited dramatic alterations after the inhibition of apoptosis. Crown height was reduced, and mesiodistal diameter was increased in a concentration-dependent manner with z-VAD-fmk treatment. Overall, apoptosis in the enamel knot would be necessary for the proper formation of molar teeth, including appropriate shape and size.

Key Words: apoptosis • tooth development • tooth shape • tooth size • macrodontia

Journal of Dental Research, Vol. 85, No. 6, 530-535 (2006)
DOI: 10.1177/154405910608500610
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