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Journal of Dental Research
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Biological

Bone Marrow Cells Can Give Rise to Ameloblast-like Cells

B. Hu1,2,3, F. Unda4, S. Bopp-Kuchler1,2, L. Jimenez4, X.J. Wang3, Y. Haïkel1,2, S.L. Wang3,* and H. Lesot1,2,*

1 INSERM, U595, Faculty of Medicine, 11 rue Humann, 67085 Strasbourg, France;
2 Faculty of Dentistry, Louis Pasteur University, 67085 Strasbourg Cedex, France;
3 Molecular Laboratory for Gene Therapy, Faculty of Stomatology, Capital University of Medical Sciences, 4 Tian Tan Xi Li, Beijing, 100050, PR China; and
4 Department of Cell Biology and Histology, Faculty of Medicine and Dentistry, University of the Basque Country, Leioa 48940, Vizcaya, Spain

Correspondence: * corresponding authors, songlinwang{at}dentist.org.cn and Herve.Lesot{at}odonto-ulp.u-strasbg.fr

Post-eruptive loss of ameloblasts requires identification of alternative sources for these cells to realize tooth-tissue-engineering strategies. Recent reports showed that bone-marrow-derived cells can give rise to different types of epithelial cells, suggesting their potential to serve as a source for ameloblasts. To investigate this potential, we mixed c-Kit+-enriched bone marrow cells with embryonic dental epithelial cells and cultured them in re-association with dental mesenchyme. Non-dividing, polarized, and secretory ameloblast-like cells were achieved without cell fusion. Before basement membrane reconstitution, some bone marrow cells migrated to the mesenchyme, where they exhibited morphological, molecular, and functional characteristics of odontoblasts. These results show, for the first time, that bone-marrow-derived cells can be reprogrammed to give rise to ameloblast-like cells, offering novel possibilities for tooth-tissue engineering and the study of the simultaneous differentiation of one bone marrow cell subpopulation into cells of two different embryonic lineages.

Key Words: bone marrow cells • tooth-tissue engineering • ameloblast • odontoblast

Journal of Dental Research, Vol. 85, No. 5, 416-421 (2006)
DOI: 10.1177/154405910608500504
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