Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

CiteULike is a free service for managing and discovering scholarly references - click here to get started.

Sign In to gain access to subscriptions and/or personal tools.
Journal of Dental Research
This Article
Right arrow Figures Only
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Right arrow Citing Articles via Scopus
Google Scholar
Right arrow Articles by Andrian, E.
Right arrow Articles by Rouabhia, M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Andrian, E.
Right arrow Articles by Rouabhia, M.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

CRITICAL REVIEWS IN ORAL BIOLOGY & MEDICINE

Porphyromonas gingivalis-Epithelial Cell Interactions in Periodontitis

E. Andrian, D. Grenier* and M. Rouabhia

Groupe de Recherche en Écologie Buccale, Faculté de médecine dentaire, Université Laval, Quebec City, Quebec, Canada, G1K 7P4

Correspondence: * corresponding author, Daniel.Grenier{at}greb.ulaval.ca

Emerging data on the consequences of the interactions between invasive oral bacteria and host cells have provided new insights into the pathogenesis of periodontal disease. Indeed, modulation of the mucosal epithelial barrier by pathogenic bacteria appears to be a critical step in the initiation and progression of periodontal disease. Periodontopathogens such as Porphyromonas gingivalis have developed different strategies to perturb the structural and functional integrity of the gingival epithelium. P. gingivalis adheres to, invades, and replicates within human epithelial cells. Adhesion of P. gingivalis to host cells is multimodal and involves the interaction of bacterial cell-surface adhesins with receptors expressed on the surfaces of epithelial cells. Internalization of P. gingivalis within host cells is rapid and requires both bacterial contact-dependent components and host-induced signaling pathways. P. gingivalis also subverts host responses to bacterial challenges by inactivating immune cells and molecules and by activating host processes leading to tissue destruction. The adaptive ability of these pathogens that allows them to survive within host cells and degrade periodontal tissue constituents may contribute to the initiation and progression of periodontitis. In this paper, we review current knowledge on the molecular cross-talk between P. gingivalis and gingival epithelial cells in the development of periodontitis.

Key Words: periodontitis • epithelial cell • Porphyromonas gingivalis • adhesion • invasion

Journal of Dental Research, Vol. 85, No. 5, 392-403 (2006)
DOI: 10.1177/154405910608500502
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?


This article has been cited by other articles:


Home page
 MicrobiologyHome page
Y. Hasegawa, J. Iwami, K. Sato, Y. Park, K. Nishikawa, T. Atsumi, K. Moriguchi, Y. Murakami, R. J. Lamont, H. Nakamura, et al.
Anchoring and length regulation of Porphyromonas gingivalis Mfa1 fimbriae by the downstream gene product Mfa2
Microbiology, October 1, 2009; 155(10): 3333 - 3347.
[Abstract] [Full Text] [PDF]

Home page
 J. Leukoc. Biol.Home page
J. C. Galicia, M. R. Benakanakere, P. G. Stathopoulou, and D. F. Kinane
Neutrophils rescue gingival epithelial cells from bacterial-induced apoptosis
J. Leukoc. Biol., July 1, 2009; 86(1): 181 - 186.
[Abstract] [Full Text] [PDF]

Home page
 MicrobiologyHome page
S.-i. Nishiyama, Y. Murakami, H. Nagata, S. Shizukuishi, I. Kawagishi, and F. Yoshimura
Involvement of minor components associated with the FimA fimbriae of Porphyromonas gingivalis in adhesive functions
Microbiology, June 1, 2007; 153(6): 1916 - 1925.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
M. A. Eskan, G. Hajishengallis, and D. F. Kinane
Differential Activation of Human Gingival Epithelial Cells and Monocytes by Porphyromonas gingivalis Fimbriae
Infect. Immun., February 1, 2007; 75(2): 892 - 898.
[Abstract] [Full Text] [PDF]