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Journal of Dental Research
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Biological

Effects of Systemic Fluoride and in vitro Fluoride Treatment on Enamel Crystals

H. Chen1, A. Czajka-Jakubowska2, N.J. Spencer1, J.F. Mansfield3, C. Robinson4 and B.H. Clarkson1,*

1 Department of Cariology, Restorative Sciences and Endodontics, University of Michigan School of Dentistry, 1011 N. University, Ann Arbor, MI 48109-1078, USA;
2 Karol Marcinkowski University of Medical Sciences, Dept. of Conservative Dentistry and Periodontology, Poznan, Poland;
3 University of Michigan Electron Microbeam Analysis Laboratory; and
4 Leeds Dental Institute, Division of Oral Biology, Leeds, England

Correspondence: * corresponding author, bricla{at}umich.edu

Systemically administered fluoride at a concentration of 75 ppm increases the surface roughness of developing enamel crystals in rats, which may be significant in advancing our understanding of the biological mechanism of fluorosis. Thus, the aim of this study was to investigate whether the increased surface roughness may be a result of surface restructuring by the direct action of fluoride at the crystal surface. We examined the fluoride dose-dependent roughening of enamel crystal surfaces in vivo, in the rat, and whether this roughening could be mimicked by the in vitro treatment of rat enamel crystals with neutral pH fluoride solutions. Our results showed that enamel crystal surface roughness increased after treatment with increasing fluoride ion concentrations, whether applied in vitro or administered systemically. This suggests a mechanism, alongside others, for the increased surface roughness of crystals in fluorotic enamel.

Key Words: dental fluorosis • enamel crystals • fluoride • AFM

Journal of Dental Research, Vol. 85, No. 11, 1042-1045 (2006)
DOI: 10.1177/154405910608501113
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A.L.J.J. Bronckers, D.M. Lyaruu, and P.K. DenBesten
The Impact of Fluoride on Ameloblasts and the Mechanisms of Enamel Fluorosis
Journal of Dental Research, October 1, 2009; 88(10): 877 - 893.
[Abstract] [Full Text] [PDF]