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Journal of Dental Research
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*COPPER, ELEMENTAL
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Clinical

The Effect of Copper on Demineralization of Dental Enamel

A.Z. Abdullah1,*, S.M. Strafford1, S.J. Brookes2 and M.S. Duggal1

1 Paediatric Dentistry and
2 Oral Biology, Leeds Dental Institute, University of Leeds, Leeds, LS2 9LU, UK

Correspondence: * corresponding author, den2aa{at}leeds.ac.uk

Previous studies have concluded that copper might inhibit enamel demineralization in vitro. Our aim was to assess the effect of copper (Cu2+), with and without amine fluoride, on human dental enamel under cariogenic challenge in situ. In a double-blind randomized four-leg crossover trial, 14 individuals wore a removable appliance containing 2 enamel slabs, 1 containing an artificial caries lesion. During each leg, the appliance was exposed twice daily to one of the test solutions: 1.25 mM CuSO4, amine fluoride (250 ppm F), copper and amine fluoride combined, or a placebo (water). A cariogenic challenge was provided in all cases by 5 daily exposures to 10% sucrose. Slabs were assessed before and after 21 days’ exposure by Knoop microhardness and transverse microradiography. Significantly less demineralization was observed with Cu2+ and fluoride in combination than with fluoride treatment alone (p < 0.05), whereas copper alone had no significant protective effect.

Key Words: amine fluoride • copper • demineralization • enamel

Journal of Dental Research, Vol. 85, No. 11, 1011-1015 (2006)
DOI: 10.1177/154405910608501107
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