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Journal of Dental Research
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Biological

Dendritic-NK Cell Interactions in P. gingivalis-specific Responses

T. Kikuchi, D.L. Willis, M. Liu, D.B. Purkall, S. Sukumar, S.E. Barbour, H.A. Schenkein and J.G. Tew*

Clinical Research Center for Periodontal Diseases, School of Dentistry, VCU, PO Box 980556, Richmond, VA 23298-0556, USA;

Correspondence: * corresponding author, tew{at}hsc.vcu.edu

Patients with localized aggressive periodontitis have type-1 cytokines in gingival crevicular fluid and high titers of IFN-{gamma}-dependent IgG2 reactive with P. gingivalis in gingival crevicular fluid and serum. Localized aggressive periodontitis monocytes spontaneously differentiate into dendritic cells that can stimulate IFN-{gamma} production by NK cells. These relationships prompted the hypothesis that P. gingivalis-dendritic cell-NK cell interactions might promote type-1 cytokine responses. Although P. gingivalis is not a potent inducer of Th1 responses, it stimulated strong IL-12 responses by monocyte-derived dendritic cells in the presence of IFN-{gamma}, and IFN-{gamma} was produced by NK cells within 24 hrs in the presence of dendritic cells. Anti-P. gingivalis IgG2 responses were enhanced by dendritic cells, and removal of NK cells reduced IFN-{gamma}- and P. gingivalis-specific IgG2. Thus, P. gingivalis-dendritic cell-NK cell interactions apparently resulted in reciprocal stimulation and increased type-1 cytokine production by both dendritic cells and NK cells, and increased P. gingivalis-specific IgG2.

Key Words: dendritic cells • NK cells • P. gingivalis • IFN-{gamma} • IgG2

Journal of Dental Research, Vol. 84, No. 9, 858-862 (2005)
DOI: 10.1177/154405910508400915
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