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Journal of Dental Research
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Biological

CSF-1 Regulation of Osteoclastogenesis for Tooth Eruption

G.E. Wise1,*, S. Yao1, P.R. Odgren2 and F. Pan1

1 Department of Comparative Biomedical Sciences, School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA 70803, USA; and
2 Department of Cell Biology, University of Massachusetts Medical School, Worcester, MA 01655, USA;

Correspondence: * corresponding author, gwise{at}vetmed.lsu.edu

The dental follicle regulates the alveolar bone resorption needed for tooth eruption. In the rat first mandibular molar, a decrease in the expression of osteoprotegerin (OPG) in the dental follicle at day 3 enables the osteoclastogenesis needed for eruption to occur. Because colony-stimulating factor-1 (CSF-1) is maximally expressed in the dental follicle at day 3, it was hypothesized that CSF-1 down-regulates OPG gene expression in the dental follicle in vivo. To test this, we compared the expression of OPG in osteopetrotic toothless (tl/tl) rats deficient in CSF-1 with expression in their normal littermates for given ages. OPG gene expression was found to be higher in the dental follicle of the tl/tl mutants than in normals. Transfecting short interfering RNA specific for CSF-1 mRNA into dental follicle cells resulted in an up-regulation of OPG expression. Thus, these studies support our hypothesis that the down-regulation of OPG needed for tooth eruption is mediated by CSF-1.

Key Words: osteoprotegerin • tooth eruption • colony-stimulating factor-1 • osteopetrotic rats • dental follicle

Journal of Dental Research, Vol. 84, No. 9, 837-841 (2005)
DOI: 10.1177/154405910508400911
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