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Journal of Dental Research
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Biological

Effects of a High-cholesterol Diet on Cell Behavior in Rat Periodontitis

T. Tomofuji, H. Kusano, T. Azuma, D. Ekuni, T. Yamamoto and T. Watanabe*

Department of Oral Health, Okayama University Graduate School of Medicine and Dentistry, 2-5-1 Shikata-cho, Okayama 700-8525, Japan;

Correspondence: * corresponding author, wyobou{at}md.okayama-u.ac.jp

Studies have shown an association between periodontitis and serum cholesterol levels. We hypothesized that high dietary cholesterol could influence periodontitis as a result of proliferation of the junctional epithelium. Rats were divided into 4 groups. Two groups were fed a regular diet, and 2 groups were fed a high-cholesterol diet. One of each dietary group was treated with periodontitis-inducing agents (lipopolysaccharide and proteases), while the other was treated with pyrogen-free water. Feeding rats with a high-cholesterol diet induced an increase in blood total cholesterol and a decrease in high-density lipoprotein cholesterol. Proliferation of the junctional epithelium with increasing bone resorption was promoted by the consumption of a high-cholesterol diet. High dietary cholesterol further increased the cell-proliferative activity of the junctional epithelium induced by lipopolysaccharide and proteases. These results suggest that high dietary cholesterol can initiate and augment periodontitis in the rat periodontitis model.

Key Words: dietary cholesterol • serum lipids • periodontitis • cell proliferation • apoptosis

Journal of Dental Research, Vol. 84, No. 8, 752-756 (2005)
DOI: 10.1177/154405910508400813
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