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Journal of Dental Research
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Biological

Regulatory T-cells Infiltrate Periodontal Disease Tissues

T. Nakajima1,2, K. Ueki-Maruyama1,3, T. Oda1,3, Y. Ohsawa1,3, H. Ito1,3, G.J. Seymour4 and K. Yamazaki1,*

1 Periodontology and Immunology, Department of Oral Health and Welfare, Niigata University Faculty of Dentistry, 5274 Gakkocho 2-ban-cho, Niigata 951-8514, Japan;
2 General Dentistry and Clinical Education Unit, Niigata University Medical and Dental Hospital, Niigata, Japan;
3 Division of Periodontology, Department of Oral Biological Science, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan; and
4 Oral Biology and Pathology, School of Dentistry, The University of Queensland, Brisbane, Australia;

Correspondence: * corresponding author, kaz{at}dent.niigata-u.ac.jp

CD4+CD25+ regulatory T (Tr) cells are critical in regulating the immune response and thereby play an important role in the defense against infection and control of autoimmune diseases. Our previous studies demonstrated the involvement of autoimmune responses in periodontitis. The aim of this study was to identify CD4+CD25+ Tr cells in periodontitis tissues and compare them with those in gingivitis tissues. Immunohistological analysis of CD4, CD25, and CTLA-4 and the gene expression analysis of FOXP3, TGF-β1, and IL-10 on gingival biopsies revealed the presence of CD4+CD25+ Tr cells in all tissues. In periodontitis, the percentage of CD4+CD25+ Tr cells increased with increasing proportions of B-cells relative to T-cells. FOXP3, a characteristic marker for CD4+CD25+ Tr cells, TGF-β1 and IL-10 were expressed more highly in periodontitis compared with gingivitis. These findings suggest that CD4+CD25+ Tr cells and possibly other regulatory T-cell populations do exist and may play regulatory roles in periodontal diseases.

Key Words: regulatory T-cell • CD25 • FOXP3 • periodontal disease • immunohistochemistry • real-time PCR

Journal of Dental Research, Vol. 84, No. 7, 639-643 (2005)
DOI: 10.1177/154405910508400711
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