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Tannerella forsythia-induced Alveolar Bone Loss in Mice Involves Leucine-rich-repeat BspA Protein

¹ Department of Oral Biology, School of Dental Medicine, State University of New York, 3435 Main Street, Buffalo, NY 14214, USA;
² Department of Microbiology, Oral Health Science Center, Tokyo Dental College, Chiba 261-8502, Japan; and
³ Department of Biology, Bates College, Lewiston, ME 04240, USA;

Correspondence: ^* corresponding author, sharmaa{at}buffalo.edu

Tannerella forsythia (formerly Bacteroides forsythus) is one of the periodontal pathogens recently implicated in the development of periodontal disease. The cell-surface-associated, as well as the secreted, leucine-rich-repeat protein (BspA) of this bacterium have been suggested to play roles in bacterial adherence, and also in inflammation, by triggering release of pro-inflammatory cytokines from monocytes and chemokines from osteoblasts, leading to inflammation and bone resorption. In this study, we sought to determine the pathogenic potential of T. forsythia and the in vivo role of the BspA protein in pathogenesis in the mouse model of infection-induced alveolar bone loss. The results showed alveolar bone loss in mice infected with the T. forsythia wild-type strain, whereas the BspA mutant was impaired. In conclusion, evidence is presented in support of T. forsythia as an important organism involved in inducing alveolar bone loss, and the BspA protein is an important virulence factor of this bacterium.

Key Words: Tannerella forsythia • alveolar bone loss • BspA protein • leucine-rich-repeat protein

Journal of Dental Research, Vol. 84, No. 5, 462-467 (2005)
DOI: 10.1177/154405910508400512


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