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Journal of Dental Research
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CRITICAL REVIEWS IN ORAL BIOLOGY & MEDICINE

Bio-adhesive Surfaces to Promote Osteoblast Differentiation and Bone Formation

A.J. García* and C.D. Reyes

Woodruff School of Mechanical Engineering, Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, 315 Ferst Drive, 2314 Petit Biotechnology Building, Atlanta, GA 30332-0363, USA;

Correspondence: * corresponding author, andres.garcia{at}me.gatech.edu

Binding of integrin adhesion receptors to extracellular matrix components, such as fibronectin and type I collagen, activates signaling pathways directing osteoblast survival, cell-cycle progression, gene expression, and matrix mineralization. Biomimetic strategies exploit these adhesive interactions to engineer bio-inspired surfaces that promote osteoblast adhesion and differentiation, bone formation, and osseointegration. These emerging initiatives focus on directing integrin binding through presentation of bio-adhesive motifs derived from extracellular matrices. These biomolecular approaches provide promising strategies for the development of biologically active implants and grafting substrates for enhanced bone repair.

Key Words: integrin • fibronectin • RGD • type I collagen • GFOGER • cell adhesion • biomaterial

Journal of Dental Research, Vol. 84, No. 5, 407-413 (2005)
DOI: 10.1177/154405910508400502
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[Abstract] [PDF]