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Journal of Dental Research
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Biological

Thiazolidinedione (Pioglitazone) Blocks P. gingivalis- and F. nucleatum, but not E. coli, Lipopolysaccharide (LPS)-induced Interleukin-6 (IL-6) Production in Adipocytes

M. Yamaguchi1, F. Nishimura1,*, H. Naruishi1, Y. Soga1, S. Kokeguchi2 and S. Takashiba1

1 Department of Patho-physiology/Periodontal Science, and
2 Oral Microbiology, Okayama University Graduate School of Medicine and Dentistry, 2-5-1 Shikata-cho, Okayama 700-8525, Japan;

Correspondence: * corresponding author, fusanori{at}md.okayama-u.ac.jp

An elevated level of C-reactive protein (CRP) predicts the future development of coronary heart disease. Periodontitis appears to up-regulate CRP. CRP is produced by hepatocytes in response to interleukin-6 (IL-6). A major source of IL-6 in obese subjects is adipocytes. We hypothesized that lipopolysaccharide (LPS) from periodontal pathogens stimulated adipocytes to produce IL-6, and that the production was suppressed by the drugs targeted against insulin resistance, thiazolidinedione (pioglitazone), since this agent potentially showed an anti-inflammatory effect. Mouse 3T3-L1 adipocytes were stimulated with E. coli, P. gingivalis, and F. nucleatum LPS. The IL-6 concentration in culture supernatants was measured. All LPS stimulated adipocytes to produce IL-6. Although pioglitazone changed adipocyte appearance from large to small, and completely suppressed P. gingivalis and F. nucleatum LPS-induced IL-6 production, E. coli LPS-induced IL-6 production was not efficiently blocked. Thus, pioglitazone completely blocked periodontal-bacteria-derived LPS-induced IL-6 production in adipocytes, a major inducer of CRP.

Key Words: diabetes • adipocyte • insulin resistance • thiazolidinedione • interleukin-6

Journal of Dental Research, Vol. 84, No. 3, 240-244 (2005)
DOI: 10.1177/154405910508400306
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G. Perriello, S. Pampanelli, P. Brunetti, C. D. Pietro, and S. Mariz
Long-term effects of pioglitazone versus gliclazide on hepatic and humoral coagulation factors in patients with type 2 diabetes
Diabetes and Vascular Disease Research, September 1, 2007; 4(3): 226 - 230.
[Abstract] [PDF]