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Journal of Dental Research
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Biological

{alpha}2 Integrin +807 Polymorphism in Drug-induced Gingival Overgrowth

M. Ogino1,2, J. Kido2, M. Bando2, N. Hayashi2, C. Wada2, T. Nagata2, F. Nishimura3, Y. Soga3, S. Takashiba3, T. Kubota4, M. Itagaki4, Y. Shimada4, H. Tai4, H. Yoshie4, N. Yamazaki5, Y. Shinohara1 and M. Kataoka1,*

1 Divison of Gene Expression, Institute for Genome Research, The University of Tokushima, Kuramoto 3-18-15, Tokushima 770-8503, Japan;
2 Department of Periodontology and Endodontology, Institute of Health Bioscience, Graduate School, The University of Tokushima;
3 Department of Pathophysiology/Periodontal Science, Okayama University Graduate School of Medical and Dentistry;
4 Divison of Periodontology, Department of Oral Biological Science, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan; and
5 Faculty of Pharmaceutical Science, University of Tokushima, Japan;

Correspondence: * corresponding author, kataoka{at}genome.tokushima-u.ac.jp

{alpha}2 integrin on fibroblasts is reported to play an important role in the induction of drug-induced gingival overgrowth, which is characterized by excessive accumulation of type I collagen in gingival connective tissue. Silent polymorphism 807 T/C within the {alpha}2 integrin gene is associated with high/low {alpha}2 integrin expression. The aim of this study was to test the hypothesis that expression of {alpha}2 integrin 807 T/C polymorphism correlates with drug-induced gingival overgrowth. A case-control study comparing 136 subjects taking calcium channel blockers (72 with vs. 64 without drug-induced gingival overgrowth) demonstrated that the frequency of the +807 C allele was significantly higher in the case group than in the controls (odds ratio, 3.61; 95% confidence interval, 2.14 – 6.10; P < 0.05). The present findings suggest that the {alpha}2 +807 C allele is one of the genetic risk factors for drug-induced gingival overgrowth.

Key Words: drug-induced gingival overgrowth • {alpha}2 integrin • SNP • collagen phagocytosis

Journal of Dental Research, Vol. 84, No. 12, 1183-1186 (2005)
DOI: 10.1177/154405910508401217
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